We present an endoscopic nipple-sparing mastectomy with immediate deep inferior epigastric perforator (DIEP) flap reconstruction in a 38-year-old woman with multifocal HER2-positive invasive ductal carcinoma following neoadjuvant chemotherapy. The procedure was performed through a single concealed axillary incision using CO₂ insufflation and endoscopic visualization, allowing controlled dissection with preservation of the skin and nipple–areolar complex. Intraoperative transillumination was used to assess flap thickness and vascularity, while retroareolar frozen section confirmed the absence of malignant involvement. Following mastectomy and axillary clearance, immediate reconstruction was performed using a DIEP flap with microvascular anastomosis to regional recipient vessels. Final histopathology demonstrated a pathological complete response (ypT0 ypN0; RCB-0). The video demonstrates the key technical steps, anatomical landmarks, and principles of combining endoscopic breast surgery with microsurgical autologous reconstruction.
No conflicts to disclose
Mathan PJ, Gandhirajan K, Bose JC, Arumugam S, Manivasagam P, Kamaldeen S. Endoscopic nipple-sparing mastectomy with immediate DIEP flap reconstruction following neoadjuvant chemotherapy for multifocal HER2-positive breast cancer: a case report. Journal of Surgical Case Reports. 2026;2026(5):rjag344. https://doi.org/10.1093/jscr/rjag344
Feng Y, Wen N, Liang F, et al. Endoscopic nipple- or skin-sparing mastectomy and immediate breast reconstruction with endoscopic harvesting of the latissimus dorsi flap: a preliminary experience of an innovative technique. Breast Journal. 2022;2022:1373899. https://doi.org/10.1155/2022/1373899
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